Interpretable network propagation with application to expanding the repertoire of human proteins that interact with SARS-CoV-2.
Jeffrey N LawKyle AkersNure TasninaCatherine M Della SantinaShay DeutschMeghana KshirsagarJudith Klein-SeetharamanMark CrovellaPadmavathy RajagopalanSimon KasifT M MuraliPublished in: GigaScience (2022)
We examine how our provenance-tracing method can be generalized to a broad class of network-based algorithms. We provide a useful resource for the SARS-CoV-2 community that implicates many previously undocumented proteins with putative functional relationships to viral infection. This resource includes potential drugs that can be opportunistically repositioned to target these proteins. We also discuss how our overall framework can be extended to other, newly emerging viruses.