Lipopolysaccharide and cAMP modify placental calcitriol biosynthesis reducing antimicrobial peptides gene expression.

Andrea Olmos-OrtízJanice García-QuirozEuclides AvilaFelipe Caldiño-SotoAli HalhaliFernando LarreaLorenza Díaz-Nieto

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)

While LPS stimulated calcitriol biosynthesis, cyclic-AMP inhibited it. LPS downregulated cathelicidin mRNA expression, whereas cyclic-AMP antagonized VD-dependent-upregulation of most antimicrobial peptides. These findings reveal LPS and cyclic-AMP involvement in dampening placental innate immunity, highlighting the importance of cyclic-AMP in the context of placental infection and suggesting its participation to facilitate bacterial survival.

Keyphrases

protein kinase
inflammatory response
gene expression
anti inflammatory
dna methylation
toll like receptor
cell wall
genome wide