Plasma and cerebrospinal fluid neurofilament light concentrations reflect neuronal damage in systemic lupus Erythematosus.
Kristoffer A ZervidesShorena JanelidzeJessika NystedtBirgitta GullstrandPetra NilssonPia C SundgrenAnders A BengtssonOskar HanssonAndreas JönsenPublished in: BMC neurology (2022)
Higher plasma NfL concentrations in NPSLE and non-NPSLE patients may indicate a higher degree of neuronal damage in SLE in general, corresponding to cognitive impairment and organ damage development. Furthermore, our results may indicate a higher degree of neuronal breakdown in patients with active SLE, also without overt clinical symptoms. NfL may serve as an indicator of neuronal damage in SLE in further studies.
Keyphrases
- systemic lupus erythematosus
- cerebrospinal fluid
- oxidative stress
- cognitive impairment
- disease activity
- cerebral ischemia
- end stage renal disease
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- subarachnoid hemorrhage
- physical activity
- patient reported outcomes
- blood brain barrier
- brain injury
- sleep quality