Increasing specificity of tandem mass spectrometry by laser-induced dissociation.
Marion GirodPublished in: Rapid communications in mass spectrometry : RCM (2018)
Mass spectrometry offers an arsenal of tools for diverse proteomic investigations. This perspective article reviews some of the recent developments in the field of coupling laser-induced dissociation with mass spectrometry (LID-MS). Strategies involving labelling with a chromophore to induce specific photo-absorption properties are considered, with a focus on specific amino acid derivatization. Some of the opportunities and challenges of LID-MS after targeted labelling for increasing specificity in complex sample analysis are discussed.
Keyphrases
- mass spectrometry
- liquid chromatography
- tandem mass spectrometry
- gas chromatography
- high performance liquid chromatography
- ultra high performance liquid chromatography
- high resolution mass spectrometry
- electron transfer
- simultaneous determination
- amino acid
- capillary electrophoresis
- solid phase extraction
- high resolution
- ms ms
- gas chromatography mass spectrometry
- multiple sclerosis
- liquid chromatography tandem mass spectrometry
- drug delivery
- systematic review
- ionic liquid