Blood-derived microRNAs are related to cognitive domains in the general population.

Konstantinos Melas Valentina Talevi Mohammed Aslam Imtiaz Rika Etteldorf Santiago Estrada Dennis M Krüger Tonatiuh Pena Centeno Nasir Ahmad Aziz Andre Fischer Monique M B Breteler

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

We investigated the association of blood-derived microRNAs with cognitive domains. Five previously identified and 14 novel microRNAs were associated with cognition. Eleven cognition-related microRNAs were also associated with cortical thickness. Identified microRNAs were linked to genes associated with neuronal functions. Results provide putative biomarkers or therapeutic targets of cognitive aging.

Keyphrases

mass spectrometry
brain injury