The potential of colchicine for lowering the risk of cardiovascular events in type 1 diabetes.
Nicklas Järvelä JohansenFilip Krag KnopPublished in: European heart journal. Cardiovascular pharmacotherapy (2023)
In type 1 diabetes, average life expectancy is reduced by more than 10 years as compared with outside of diabetes. Residual cardiovascular risk defines high cardiovascular event rate despite modern, guideline-recommended standard of care of established risk factors like hypertension, dyslipidaemia, and glycaemic control, and it adds importantly to these lost years of life in type 1 diabetes due to atherosclerotic cardiovascular disease like myocardial infarction and ischaemic stroke. With growing understanding of inflammation as an important driver of atherosclerotic cardiovascular disease, residual inflammatory risk is a novel and common risk factor and a promising target for lowering residual cardiovascular risk in type 1 diabetes. Interestingly, the inexpensive anti-inflammatory agent colchicine reduced risk of major adverse cardiovascular events by 25% in cardiovascular outcome trials in the secondary prevention of atherosclerotic cardiovascular disease. Here, we summarise the role of inflammation as a driver of atherosclerosis and review current evidence linking inflammation and atherosclerotic cardiovascular disease in type 1 diabetes. Also, we provide an overview of the evidence base for targeting residual inflammatory risk with colchicine for lowering residual cardiovascular risk in type 1 diabetes.
Keyphrases
- type diabetes
- cardiovascular disease
- cardiovascular events
- glycemic control
- oxidative stress
- risk factors
- coronary artery disease
- cardiovascular risk factors
- healthcare
- blood pressure
- anti inflammatory
- emergency department
- palliative care
- metabolic syndrome
- adipose tissue
- chronic pain
- left ventricular
- atrial fibrillation