Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.
Pamela BowmanFrances MathewsFabrizio BarbettiMaggie H ShepherdJanine SanchezBarbara PicciniJacques BeltrandLisa R Letourneau-FreibergMichel PolakSiri Atma W GreeleyEamon RawlinsTarig BabikerNicholas J ThomasElisa De FrancoSian EllardSarah E FlanaganAndrew T Hattersleynull nullPublished in: Diabetes care (2020)
Sulfonylurea treatment of ABCC8-PNDM results in excellent long-term glycemic control. Overt neurological features frequently occur and may improve with sulfonylureas, supporting early, rapid genetic testing to guide appropriate treatment and neurodevelopmental assessment.