Modulation of the tumor microenvironment by armed vesicular stomatitis virus in a syngeneic pancreatic cancer model.
Sijia TangLei ShiBreona T LukerChannen MicklerBhavana SureshGregory B LesinskiDaping FanYuan LiuMing LuoPublished in: Virology journal (2022)
The improved OV, VSV-S, was shown to drastically alter the immune suppressive tumor microenvironment when intratumorally injected. Our results suggest that the combination of potent OV treatment with immune checkpoint blockade may be a promising strategy to treat pancreatic cancer more effectively.
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