Regulation of YAP Promotor Accessibility in Endothelial Mechanotransduction.
Aarren J MannionHonglei ZhaoYuanyuan ZhangYlva von WrightOtto BergmanJoy RoyPipsa SaharinenLars HolmgrenPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our findings reveal a role for AmotL2 and nuclear-cytoskeletal force transmission in modulating the epigenetic and transcriptional regulation of YAP to maintain a mechano-enforced positive feedback loop of vascular homeostasis. These findings may offer an explanation as to the proinflammatory phenotype that leads to aneurysm formation observed in AmotL2 endothelial deletion models.