TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea.

Yazhi XingKun PengQian YiDongzhen YuHaibo ShiGuang YangShankai Yin

Published in: Cellular & molecular biology letters (2023)

Deletion of TMEM30A led to disrupted planar polarity and stereocilia bundles, and finally led to hair cell loss and auditory dysfunction. TMEM30A is essential for hair cell polarity maintenance and membrane homeostasis. Our study highlights a pivotal role of TMEM30A in the postnatal development of hair cells and reveals the possible mechanisms underlying P4-ATPase-related genetic hearing loss.

Keyphrases

single cell
cell therapy
hearing loss
preterm infants
stem cells
oxidative stress
gene expression
endoplasmic reticulum