Frequency of pathogenic/likely pathogenic germline variants in cancer-related genes among children with acute leukemia in Saudi Arabia.
Abdulrahman AlsultanMohammed F EssaAbdullah AljefriMouhab F AyasMusa AlharbiNawaf AlkhayatFaisal Al-AnziFawwaz YassinFawaz AlkasimQasim AlharbiShaker AbdullahOmima MustafaPublished in: Pediatric blood & cancer (2020)
Children with acute leukemia in Saudi Arabia had low frequency of P/LP mutations in cancer-related genes despite the high rate of consanguinity. Larger studies using whole-genome sequencing are needed to further explore the heritability of childhood leukemia.