Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer's risk-enhanced sample.
Lianlian DuRebecca E LanghoughRachael E WilsonRamiro Eduardo Rea ReyesBruce P HermannErin M JonaitisTobey J BetthauserNathaniel A ChinBradley ChristianLauren ChabyAndreas JerominGuglielmo Di MolfettaWagner S BrumBurak ArslanNicholas AshtonKaj BlennowHenrik ZetterbergSterling C JohnsonPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Phosphorylated-tau217 (p-tau217) trajectories were significantly different in people who were known to be amyloid positive. Subtle age-related trajectories were seen for all the plasma markers in amyloid-negative cognitively unimpaired. Kidney function and body mass index were not associated with plasma p-tau217 trajectories. Higher plasma p-tau217 was associated with faster preclinical cognitive decline.