American Heart Association's Life's Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease.

Natalie R HasbaniSymen LigthartMichael R Brown Adam S HeathAllison BeboKellan E AshleyEric BoerwinkleAlanna C Morrison Aaron R Folsom David Aguilar Paul S de Vries

Published in: Circulation (2022)

Ideal adherence to LS7 recommendations was associated with lower lifetime risk of CHD for all individuals, especially in those with high genetic susceptibility. In Black participants, adherence to LS7 guidelines contributed to lifetime risk of CHD more so than current PRSs. Improved PRSs are needed to properly evaluate genetic susceptibility for CHD in diverse populations.

Keyphrases

clinical practice
genome wide
copy number
metabolic syndrome
heart failure
cardiovascular disease
physical activity
weight loss
type diabetes
glycemic control
atrial fibrillation
gene expression
dna methylation