Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau.

Brandon FrankMadeline AllyBailee BrekkeHenrik ZetterbergKaj BlennowMichael A SugarmanNicholas J AshtonThomas K KarikariYorghos TripodisBrett MartinJoseph N PalmisanoEric G SteinbergIrene SimkinaKatherine W TurkAndrew E BudsonMaureen K O'ConnorRhoda AuLee E GoldsteinGyungah R JunNeil W KowallThor D SteinAnn C McKeeRonald KillianyWei Qiao QiuRobert A SternJesse MezMichael L Alosco

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)

These results support plasma p-tau181 for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection.

Keyphrases

cerebrospinal fluid
mild cognitive impairment
loop mediated isothermal amplification
cognitive impairment
cognitive decline
label free
real time pcr
sensitive detection