Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy.

Rasmus Erik Johansson MortensenMorten Orebo HolmströmThomas Landkildehus LisleJane P HasselbyGro L WillemoeÖzcan MetInge Marie SvaneJulia JohansenDorte L NielsenInna M ChenMads Hald Andersen

Published in: Journal for immunotherapy of cancer (2023)

in patients without spontaneous responses. Taken together, our data suggest that combining TGF-β-based vaccination with ICI/radiotherapy will be beneficial for patients with PC.

Keyphrases

early stage
end stage renal disease
transforming growth factor
newly diagnosed
radiation therapy
ejection fraction
locally advanced
radiation induced
dna damage
peritoneal dialysis
cell cycle
squamous cell carcinoma
oxidative stress
electronic health record
big data
machine learning
patient reported
deep learning