N-acetylcysteine for major mental disorders: a systematic review and meta-analysis of randomized controlled trials.

W ZhengQ-E ZhangD-B CaiX-H YangY QiuG S UngvariC H NgM BerkY-P NingYu-Tao Xiang

Published in: Acta psychiatrica Scandinavica (2018)

Adjunctive NAC appears to be a safe treatment that has efficacy for schizophrenia, but not for bipolar disorder or MDD. Further higher quality RCTs are warranted to determine the role of adjunctive NAC in the treatment of major psychiatric disorders.

Keyphrases

bipolar disorder
major depressive disorder
transcription factor
combination therapy
quality improvement