Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy.
Minsu KimSeok Chan ParkDong Yun LeePublished in: Cancers (2021)
Chemotherapy is used widely for cancer treatment; however, the evolution of multidrug resistance (MDR) in many patients limits the therapeutic benefits of chemotherapy. It is important to overcome MDR for enhanced chemotherapy. ATP-dependent efflux of drugs out of cells is the main mechanism of MDR. Recent studies have suggested that nitric oxide (NO) can be used to overcome MDR by inhibiting the ATPase function of ATP-dependent pumps. Several attempts have been made to deliver NO to the tumor microenvironment (TME), however there are limitations in delivery. Glycyrrhizin (GL), an active compound of licorice, has been reported to both reduce the MDR effect by inhibiting ATP-dependent pumps and function as a regulator of NO production in the TME. In this review, we describe the potential role of GL as an NO regulator and MDR inhibitor that efficiently reduces the MDR effect in cancer chemotherapy.
Keyphrases
- multidrug resistant
- nitric oxide
- locally advanced
- papillary thyroid
- transcription factor
- end stage renal disease
- induced apoptosis
- signaling pathway
- newly diagnosed
- rectal cancer
- squamous cell carcinoma
- oxidative stress
- radiation therapy
- nitric oxide synthase
- prognostic factors
- cell proliferation
- climate change
- endoplasmic reticulum stress
- drug induced
- human health
- patient reported