Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline.
Ilkka K MartikainenNina KemppainenJarkko JohanssonJarmo TeuhoSemi HelinYawu LiuS HelisalmiHilkka SoininenRiitta ParkkolaTiia NganduMiia KivipeltoJuha O RinnePublished in: AJNR. American journal of neuroradiology (2018)
Our results show a significant association between increases in brain β-amyloid and reductions in regional GM volume in individuals at increased risk of cognitive decline. This evidence is consistent with a model in which increases in β-amyloid incite neurodegeneration in memory systems before cognitive impairment manifests.