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Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the CD247 locus.

Sangjoon LahSegi KimIn KangHyojin KimCedric HupperetzHyuncheol JungHyeong Ryeol ChoiYoung-Ho LeeHyeon-Ki JangSangsu BaeChan Hyuk Kim
Published in: Journal for immunotherapy of cancer (2023)
Our findings offer a promising strategy for improving the intracellular signaling of TCR-T cells and their application in treating solid tumors.
Keyphrases
  • regulatory t cells
  • dendritic cells
  • reactive oxygen species
  • dna binding
  • binding protein
  • nk cells
  • genome wide association study
  • transcription factor