Rapid whole-blood assay to detect SARS-CoV-2-specific memory T-cell immunity following a single dose of AstraZeneca ChAdOx1-S COVID-19 vaccine.

Katie E LineburgMichelle A NellerGeorge R AmbalathingalLaetitia Le TexierJyothy RajuSrividhya SwaminathanLea LekieffreCaitlyn SmithSweera RehanPauline CrooksArchana PanikkarSriganesh SrihariRajiv KhannaCorey Smith

Published in: Clinical & translational immunology (2021)

The whole-blood cytokine assay provides a rapid approach to assessing T-cell immunity against SARS-CoV-2 in vaccine recipients. While the majority of participants generated a robust SARS-CoV-2-specific T-cell response following their first dose, some did not, demonstrating the likely importance of the booster dose in improving T-cell immunity.

Keyphrases

sars cov
respiratory syndrome coronavirus
high throughput
loop mediated isothermal amplification
working memory
coronavirus disease
sensitive detection
single cell