Simulation study of a coincidence detection system for non-invasive determination of arterial blood time-activity curve measurements.

Initial simulations demonstrated that the configuration of a single half-ring 8 detector of monolithic BGO crystals could describe the simulated BTAC in a clinically relevant forearm phantom with good signal properties, and an increased number of axial detection rings can provide increased sensitivity of the system. The system would find use in the derivation of the BTAC for use in the application of kinetic models without physical arterial sampling or reliance on image-based techniques.