A two-photon responsive hydroxyphenylquinazolinone (HPQ)-based fluorescent organic nanoprodrug for H 2 S release against oxidative stress.
Amrita ChaudhuriTara SinghaBikash Chandra JenaManiklal SheePrasanta Kumar DattaMahitosh MandalN D Pradeep SinghPublished in: Chemical communications (Cambridge, England) (2023)
Light-activated H 2 S donors have attracted considerable interest in understanding the physiological role and clinical potential of H 2 S, as their release is highly localized and controlled. Herein, we have evolved a new HPQ chromophore-based fluorescent organic nanosystem localized in a target area that tolerates oxidative stress and precisely releases H 2 S under one- and two-photon irradiation with real-time monitoring capability. The two-photon absorption cross-section of this new phototrigger was calculated to be 283 GM at 720 nm. H 2 S photorelease was also demonstrated in vitro on the MDA-MB-468 cell line in the presence of excess ROS. Our developed H 2 S nanoprodrug can be applied to living systems to release the H 2 S-gasotransmitter under laser irradiation in a phototherapeutic window.
Keyphrases
- living cells
- oxidative stress
- fluorescent probe
- dna damage
- quantum dots
- single molecule
- diabetic rats
- ischemia reperfusion injury
- monte carlo
- water soluble
- cell death
- photodynamic therapy
- radiation induced
- breast cancer cells
- risk assessment
- high speed
- radiation therapy
- cell proliferation
- drug delivery
- high resolution