Association between premature vascular smooth muscle cells senescence and vascular inflammation in Takayasu's arteritis.

Chenglong FangLihong DuShang GaoYuexin ChenZuoguan ChenZhiyuan WuLili LiJing Li Xiao-Feng Zeng Meng Tao LiYongjun LiXinping Tian

Published in: Annals of the rheumatic diseases (2024)

VSMCs present features of cellular senescence and are actively involved in vascular inflammation in TAK. Vascular IL-6-mitochondrial STAT3-MFN2 signalling is an important driver of VSMCs senescence.

Keyphrases

vascular smooth muscle cells
oxidative stress
dna damage
angiotensin ii
endothelial cells
stress induced
cell proliferation