Epidemiology of intravenous immune globulin in septic shock: a retrospective cohort analysis of the Premier Healthcare Database.
Murdoch LeeiesHayley B GershengornEmmanuel CharbonneyAnand KumarDean A FergussonAlexis F TurgeonAllan GarlandDonald S HoustonBrett HoustonEmily RimmerEric JacobsohnSrinivas MurthyRob FowlerRobert BalshawRyan ZarychanskiPublished in: Canadian journal of anaesthesia = Journal canadien d'anesthesie (2021)
Intravenous immune globulin is used infrequently across the US in patients with septic shock. Regimens of IVIG in septic shock may be less intensive than those associated with a survival benefit in meta-analyses. Observed infrequent use supports apparent clinical equipoise, perhaps secondary to limitations of the primary literature. A clinical trial evaluating the role of IVIG in septic shock is needed.