Palladium-Catalyzed Synthesis of 3-Haloindol-2-amines from 3-Diazoindolin-2-imines and Alkyl Halides.

Synthetically valuable 3-haloindol-2-amines were prepared from readily available 3-diazoindolin-2-imines and a variety of alkyl halides through the palladium-catalyzed reaction. The broad substrate scope of both diazo compounds and alkyl halides, mild reaction conditions, and high efficiency are the main characters of this method. The synthesized 3-haloindol-2-amines can be conveniently transformed to more complex indole derivatives.