Ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome.

Núria Dueñas Hannah KlinkhammerNuria BonifaciIsabel SpierAndreas MayrEmadeldin HassaninAnna Diez-VillanuevaVictor Moreno Marta PinedaCarlo MajGabriel CapellàStefan Aretz Joan Brunet

Published in: Journal of medical genetics (2023)

The PRS may slightly influence CRC risk in individuals with LS in particular in more extreme phenotypes such as early-onset disease. However, the study design and recruitment strategy strongly influence the results of PRS studies. A separate analysis by genes and its combination with other genetic and non-genetic risk factors will help refine its role as a risk modifier in LS.

Keyphrases

early onset
risk factors
genome wide
late onset
climate change
dna methylation
gene expression
case control