Ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome.
Núria DueñasHannah KlinkhammerNuria BonifaciIsabel SpierAndreas MayrEmadeldin HassaninAnna Diez-VillanuevaVictor MorenoMarta PinedaCarlo MajGabriel CapellàStefan AretzJoan BrunetPublished in: Journal of medical genetics (2023)
The PRS may slightly influence CRC risk in individuals with LS in particular in more extreme phenotypes such as early-onset disease. However, the study design and recruitment strategy strongly influence the results of PRS studies. A separate analysis by genes and its combination with other genetic and non-genetic risk factors will help refine its role as a risk modifier in LS.