Functional effects of an African glucose-6-phosphate dehydrogenase (G6PD) polymorphism (Val68Met) on red blood cell hemolytic propensity and post-transfusion recovery.

Ling WangElizabeth R RochonSebastien GingrasBenjamin E ZuchelkowskiDerek J SincharElimira AlipourJulie A ReiszMinying YangGrier P PageTamir KaniasDarrell J TriulziJanet S LeeDaniel B Kim-ShapiroAngelo D'AlessandroMark T Gladwin

Published in: Transfusion (2024)

This novel mouse model of the common G6PD A- variant has impaired antioxidant capacity like humans and low G6PD activity may reduce survival of transfused RBCs when irradiation is performed.

Keyphrases

red blood cell
mouse model
cardiac surgery
tyrosine kinase
metabolic syndrome
type diabetes
radiation therapy
blood pressure
acute kidney injury
adipose tissue
free survival