Desulfovibrio confers resilience to the comorbidity of pain and anxiety in a mouse model of chronic inflammatory pain.

Zifeng WuHanyu LiuEnshi YanXinying ZhangYuanyuan WangChaoli HuangTeng HeLiying MiaoLing YangRiyue JiangChangyong QiCunming LiuDi WangChun Yang

Published in: Psychopharmacology (2022)

Abnormal composition of gut microbiota plays an essential role in chronic pain as well as in anxiety. Besides, the increased level of Desulfovibrio in anxiety-resilient mice indicated its therapeutic effects on the comorbidity of pain and anxiety. Collectively, targeting gut microbiota, especially increasing the Desulfovibrio level, might be effective in the alleviation of chronic pain-anxiety comorbidity.

Keyphrases

chronic pain
pain management
sleep quality
mouse model
oxidative stress
type diabetes
physical activity
spinal cord
depressive symptoms
adipose tissue
drug induced