A systematic two-sample and bidirectional MR process highlights a unidirectional genetic causal effect of allergic diseases on COVID-19 infection/severity.
Xiao-Tong ChenShuai ZhiXin-Yu HanJian-Wei JiangGuang-Ming LiuShi-Tao RaoPublished in: Journal of translational medicine (2024)
Our systematic and bidirectional MR analyses suggest a unidirectional causal effect of various ADs, particularly of asthma on COVID-19 infection/severity, but the reverse is not true. The potential underlying molecular mechanisms of the causal effects call for more attention to clinical monitoring of hematological cells/traits and may be beneficial in developing effective therapeutic strategies for allergic patients following infection with COVID-19.
Keyphrases
- end stage renal disease
- allergic rhinitis
- newly diagnosed
- coronavirus disease
- ejection fraction
- sars cov
- induced apoptosis
- chronic obstructive pulmonary disease
- chronic kidney disease
- magnetic resonance
- genome wide
- prognostic factors
- working memory
- contrast enhanced
- cell cycle arrest
- magnetic resonance imaging
- gene expression
- patient reported outcomes
- lung function
- oxidative stress
- cell death
- risk assessment
- copy number
- cystic fibrosis
- air pollution
- endoplasmic reticulum stress