Hippocampal transcriptome reveals novel targets of FASD pathogenesis.

Raine Lunde-YoungJosue RamirezVishal NaikMarcus OrzabalJehoon LeeKranti KongantiAndrew HillhouseDavid ThreadgillJayanth Ramadoss

Published in: Brain and behavior (2019)

We conclude that chronic binge alcohol exposure during pregnancy dysregulates fetal hippocampal gene expression in a sex-specific manner. Identification of subtle, transcriptome-level dysregulation in hippocampal molecular pathways offers potential mechanistic insights underlying FASD pathogenesis.

Keyphrases

gene expression
cerebral ischemia
rna seq
single cell
genome wide
dna methylation
temporal lobe epilepsy
single molecule
brain injury
human health