Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization.

Chenfei WangXiaobei HuangLitao SunQiuxia LiZhili LiHaiyang YongDelu CheCong YanSongmei GengWenxin Wang Dezhong Zhou

Published in: Chemical communications (Cambridge, England) (2022)

Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.

Keyphrases

copy number
genome wide
genome wide identification
dna methylation
single molecule
transcription factor
neural network