Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis.

Marta Pulido-SalgadoJose M Vidal-TaboadaGerardo Garcia Diaz-BarrigaJoan SerratosaTony ValentePaola CastilloJonathan MatalongaMarco StracciaJosep M CanalsAnnabel ValledorCarme SolàJosep Saura

Published in: Journal of neuroinflammation (2017)

This study provides new data that support a central role for C/EBPβ in the biology of activated microglia, and it offers proof of concept for the therapeutic potential of microglial C/EBPβ inhibition in multiple sclerosis.

Keyphrases

gene expression
inflammatory response
multiple sclerosis
neuropathic pain
lipopolysaccharide induced
lps induced
dna methylation
electronic health record
dendritic cells
white matter
immune response
replacement therapy