Evidence of Alternative Modes of B Cell Activation Involving Acquired Fab Regions of N-Glycosylation in Antibody-Secreting Cells Infiltrating the Labial Salivary Glands of Patients With Sjögren's Syndrome.

Kristi A KoelschJoshua CavettKenneth SmithJacen S MooreSylvain D LehouxNan JiaTim MatherSyed M S QuadriAstrid RasmussenC Erick KaufmanDavid M LewisLida RadfarTeresa A ScordinoChristopher J LessardBiji T KurienRichard D CummingsJudith A JamesKathy L SivilsA Darise FarrisRobert Hal Scofield

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2018)

These findings support the notion of an alternative mechanism for the selection and proliferation of some autoreactive B cells, involving V-region N-glycosylation, in patients with SS.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
case report
endoplasmic reticulum stress
disease activity
oxidative stress
rheumatoid arthritis
cell proliferation