Molecular markers of telomere dysfunction and senescence are common findings in the usual interstitial pneumonia pattern of lung fibrosis.
Joyce S LeeJanet LaSara AzizEvgenia DobrinskikhRobert BrownellKirk D JonesNatalia Achtar-ZadehGary GreenBrett M ElickerJeffrey A GoldenMichael A MatthayJasleen KukrejaDavid A SchwartzPaul J WoltersPublished in: Histopathology (2021)
Molecular markers of telomere dysfunction and senescence are pathologically expressed in both IPF and non-IPF UIP lungs. These findings suggest that common molecular drivers may contribute to the pathogenesis of UIP-associated pulmonary fibrosis, regardless of the clinical diagnosis.