miR-31/QKI-5 axis facilitates cell cycle progression of non-small-cell lung cancer cells by interacting and regulating p21 and CDK4/6 expressions.

Wangyu ZhuYun YuKexin FangSisi XiaoLianli NiChangtian YinXiangjie HuangXinchen WangYongkui ZhangHan-Bo LeRi Cui

Published in: Cancer medicine (2022)

Our results suggest that the miR-31/QKI-5/p21-CDK4-CDK6 axis might have critical functions in the progression of NSCLC, and targeting this axis could serve as a potential therapeutic strategy for NSCLC.

Keyphrases

cell cycle
cell proliferation
small cell lung cancer
long non coding rna
advanced non small cell lung cancer
long noncoding rna
cell therapy
stem cells
mesenchymal stem cells
bone marrow
epidermal growth factor receptor