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Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway.

Sanja B TurturroMatthew S NajorTimothy YungLiam PorttChristopher S MalarkeyAbde M AbukhdeirMelody A Cobleigh
Published in: Breast cancer research and treatment (2019)
Our findings suggest that breast cancers with loss of p85α may not respond to mTOR inhibition, but may be sensitive to MEK inhibition.
Keyphrases
  • pi k akt
  • signaling pathway
  • cell proliferation
  • oxidative stress
  • copy number
  • gene expression
  • dna methylation