Cell-therapy for Parkinson's disease: a systematic review and meta-analysis.

Fang WangZhengwu SunDaoyong PengShikha GianchandaniWeidong LeJohannes BoltzeShen Li

Published in: Journal of translational medicine (2023)

This meta-analysis provides preliminary evidence for the beneficial effects of homogenous cell-therapy for PD, potentially to the levodopa responders. Allogeneic cells were superior to autologous cells, and the effective transplantation sites are not limited to the basal ganglia. PROSPERO registration number: CRD42022369760.

Keyphrases

cell therapy
induced apoptosis
systematic review
stem cells
cell cycle arrest
mesenchymal stem cells
bone marrow
endoplasmic reticulum stress
stem cell transplantation
oxidative stress
single cell
signaling pathway
meta analyses
low dose
cell proliferation
high dose