Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7-acetylated and cytoplasm-translocated G protein GαS.

Ye ZhouKaiwei JiaSuyuan WangZhenyang LiYunhui LiShan LuYingyun YangLiyuan ZhangMu WangYue DongLuxin ZhangWannian ZhangNan LiYizhi YuXuetao CaoJin Hou

Published in: Hepatology (Baltimore, Md.) (2022)

Malignant progression of HcPCs requires increased K28-acetylated and cytoplasm-translocated GαS, causing enhanced response to IL-6 and driving premalignant HcPCs to fully established HCC, which provides mechanistic insight and a potential target for preventing hepatocarcinogenesis.

Keyphrases

human health
risk assessment