Antibiotic-induced dysbiosis of the microbiota impairs gut neuromuscular function in juvenile mice.

Valentina CaputiIlaria MarsilioViviana FilpaSilvia CerantolaGenny OrsoMichela BistolettiNicola PaccagnellaSara De MartinMonica MontopoliStefano Dall'AcquaFrancesca CremaIole-Maria Di GangiFrancesca GaluppiniIsabella LanteSara BogialliMassimo RuggePatrizia DebettoCristina GiaroniMaria Cecilia Giron

Published in: British journal of pharmacology (2017)

Gut dysbiosis caused complex morpho-functional neuromuscular rearrangements, characterized by structural defects of the ENS and increased tachykininergic neurotransmission. Altogether, our findings support the beneficial role of enteric microbiota for ENS homeostasis instrumental in ensuring proper gut neuromuscular function during critical stages of development.

Keyphrases

high glucose
diabetic rats
type diabetes
metabolic syndrome
drug induced
oxidative stress
adipose tissue
skeletal muscle