Clinical phenotype and cytokine profile of adult IgA vasculitis with joint involvement.
Alice DelapierreBenjamin TerrierEvangéline PilleboutPauline BaudartNoémie Jourde-ChicheBertrand LiogerNihal MartisGuillaume MoulisEtienne RivièreNoémie Le GouellecLoïc RaffrayGeoffrey UrbanskiSébastien SangesFrancois MaurierAlban DerouxArsène MekinianRenato MonteiroChristian MarcelliLoïc GuillevinFrancois MaillotBruno LucasAchille AoubaAlexandra Audemard-Vergernull nullPublished in: Clinical rheumatology (2022)
Joint involvement is frequent in adult IgAV and is associated with more frequent gastrointestinal involvement. Increased plasma IL-1β levels raise the question of targeting this cytokine in patients with chronic and/or refractory joint involvement. Key Points • Joint involvement in adult IgAV is a frequent manifestation. • Joint involvement is associated with more frequent gastrointestinal manifestations. • Interleukin-1β (IL-1β) might orchestrate joint inflammation in adult IgAV. • IL-1β might be a therapeutic target in patients with chronic and/or refractory joint involvement.