Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using 68Ga-FAPI-04.
Susan NotohamiprodjoStephan G NekollaStephanie RobuAlberto Villagran AsiaresChristian KupattTareq IbrahimKarl-Ludwig LaugwitzMarcus R MakowskiMarkus SchwaigerWolfgang Andreas WeberZohreh VarastehPublished in: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (2021)
Our previous study has demonstrated the feasibility of noninvasive imaging of fibroblast activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory in a rat model with 68Ga-FAPI-04-PET. In the current extended clinical case, we sought to delineate cardiac uptake of 68Ga-FAPI-04 in a patient after MI with clinical indication for the evidence of fibroblast activation. Carcinoma patients without cardiac disease underwent 68Ga-FAPI-04-PET/CT as control. The patient with one-vessel disease underwent dynamic 68Ga-FAPI-04-cardiac-PET/CMR for 60 minutes. Correlation of cardiac 68Ga-FAPI-04 uptake with clinical findings, ECG, echocardiography, coronary-arteriography and enhanced cardiac-MRI with T1 MOLLI and ECV mapping were performed. No uptake was found in normal myocardium and in mature scar. A focal intense 68Ga-FAPI-04 uptake with continuous wash-out in the infarct territory of coronary occlusion correlating with T1 and ECV mapping was observed. The uptake of 68Ga-FAPI-04 extends beyond the actual infarcted area and overestimates the infarct size as confirmed by follow-up CMR.
Keyphrases
- pet ct
- left ventricular
- acute myocardial infarction
- positron emission tomography
- high resolution
- coronary artery disease
- case report
- coronary artery
- end stage renal disease
- computed tomography
- newly diagnosed
- heart failure
- acute coronary syndrome
- chronic kidney disease
- percutaneous coronary intervention
- pulmonary hypertension
- magnetic resonance
- small molecule
- wound healing
- heart rate
- high density
- photodynamic therapy