The Causal Effect of Systolic Blood Pressure Lowering on Vascular Outcomes in Diabetes: A Mendelian Randomization Study.

Tianzhichao HouMian LiHong LinZhiyun ZhaoJieli LuTian-Ge WangYu XuWeiqing Wang Yu-Fang Bi Yanqiu Wang Yanan Hou

Published in: The Journal of clinical endocrinology and metabolism (2022)

SBP lowering was causally associated with an attenuated risk of diabetic CAD and nephropathy. It provides genetic evidence for the beneficial effect of lifelong SBP control in preventing diabetes-related vascular outcomes.

Keyphrases

blood pressure
type diabetes
glycemic control
cardiovascular disease
heart failure
left ventricular
heart rate
genome wide
dna methylation
gene expression
metabolic syndrome
adipose tissue
insulin resistance
weight loss