Effect of bone marrow aspiration concentrate and platelet-rich plasma combination in anterior cruciate ligament reconstruction: a randomized, prospective, double-blinded study.
Yu-Chuan LinYu-Jen ChenTsang-Yu FanPei-Hsi ChouCheng-Chang LuPublished in: Journal of orthopaedic surgery and research (2024)
PRP alone and BMAC and PRP combination showed limited enhancing effect in clinical function, graft maturation and tendon-bone interfacial healing compared with control (no additional treatment). When BMAC is used in ACL reconstruction, the possibility of greater inflammation in the early stage to graft maturation and bone tunnel healing should be considered.
Keyphrases
- platelet rich plasma
- anterior cruciate ligament reconstruction
- early stage
- bone marrow
- bone mineral density
- oxidative stress
- mesenchymal stem cells
- soft tissue
- bone loss
- bone regeneration
- ionic liquid
- molecular dynamics simulations
- squamous cell carcinoma
- body composition
- radiation therapy
- combination therapy
- neoadjuvant chemotherapy