Aberrant Extrafollicular B Cells, Immune Dysfunction, Myeloid Inflammation, and MyD88-Mutant Progenitors Precede Waldenstrom Macroglobulinemia.
Akhilesh KaushalAjay K NookaAllison R CarrKatherine E PendletonBenjamin G BarwickRenee Julia ManaloSamuel S McCachrenVilas A GuptaNisha S JosephCraig C HofmeisterJonathan L KaufmanLeonard T HeffnerStephen M AnsellLawrence H BoiseSagar LonialKavita M DhodapkarMadhav V DhodapkarPublished in: Blood cancer discovery (2021)
These data provide evidence that growth of the malignant clone in WM is preceded by expansion of extrafollicular B cells, myeloid inflammation, and immune dysfunction in the preneoplastic phase. These changes may be related in part to MYD88 oncogenic signaling in pre-B progenitor cells and suggest a novel model for WM pathogenesis. This article is highlighted in the In This Issue feature, p. 549.