Aberrant Extrafollicular B Cells, Immune Dysfunction, Myeloid Inflammation, and MyD88-Mutant Progenitors Precede Waldenstrom Macroglobulinemia.

Akhilesh KaushalAjay K NookaAllison R CarrKatherine E Pendleton Benjamin G Barwick Renee Julia Manalo Samuel S McCachren Vilas A GuptaNisha S JosephCraig C Hofmeister Jonathan L KaufmanLeonard T HeffnerStephen M Ansell Lawrence H BoiseSagar LonialKavita M DhodapkarMadhav V Dhodapkar

Published in: Blood cancer discovery (2021)

These data provide evidence that growth of the malignant clone in WM is preceded by expansion of extrafollicular B cells, myeloid inflammation, and immune dysfunction in the preneoplastic phase. These changes may be related in part to MYD88 oncogenic signaling in pre-B progenitor cells and suggest a novel model for WM pathogenesis. This article is highlighted in the In This Issue feature, p. 549.

Keyphrases

oxidative stress
dendritic cells
toll like receptor
bone marrow
acute myeloid leukemia
machine learning
electronic health record
transcription factor
big data
deep learning
inflammatory response