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Aberrant Extrafollicular B Cells, Immune Dysfunction, Myeloid Inflammation, and MyD88-Mutant Progenitors Precede Waldenstrom Macroglobulinemia.

Akhilesh KaushalAjay K NookaAllison R CarrKatherine E PendletonBenjamin G BarwickRenee Julia ManaloSamuel S McCachrenVilas A GuptaNisha S JosephCraig C HofmeisterJonathan L KaufmanLeonard T HeffnerStephen M AnsellLawrence H BoiseSagar LonialKavita M DhodapkarMadhav V Dhodapkar
Published in: Blood cancer discovery (2021)
These data provide evidence that growth of the malignant clone in WM is preceded by expansion of extrafollicular B cells, myeloid inflammation, and immune dysfunction in the preneoplastic phase. These changes may be related in part to MYD88 oncogenic signaling in pre-B progenitor cells and suggest a novel model for WM pathogenesis. This article is highlighted in the In This Issue feature, p. 549.
Keyphrases
  • oxidative stress
  • dendritic cells
  • toll like receptor
  • bone marrow
  • acute myeloid leukemia
  • machine learning
  • electronic health record
  • transcription factor
  • big data
  • deep learning
  • inflammatory response