Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection.

Carolyn D AlonsoNira R PollockKevin W GareyAnne J Gonzales-LunaDavid N WilliamsKaitlyn DaughertyChristine CuddemiJavier A Villafuerte GálvezNicole C WhiteXinhua ChenHua XuRebecca SpragueCaitlin BarrettMark MillerAgnès FoussadierAude LantzAlice BanzCiarán P Kelly

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the North American pulsed-field gel electrophoresis type 1/ribotype 027 (NAP-1/027) strain compared with other strains, providing in vivo confirmation of the in vitro association between NAP-1/027 and elevated toxin production.

Keyphrases

clostridium difficile
escherichia coli
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
patient reported outcomes
simultaneous determination