A five-CpG DNA methylation score to predict metastatic-lethal outcomes in men treated with radical prostatectomy for localized prostate cancer.

Shanshan ZhaoAmy LeonardsonMilan S GeybelsAndrew S McDanielMing YuSuzanne KolbHong ZongKelly CarterJaved SiddiquiAnqi ChengJonathan L WrightColin C PritchardRaymond LanceDean TroyerJian-Bing FanElaine A OstranderJames Y DaiScott A TomlinsZiding FengJanet L Stanford

Published in: The Prostate (2018)

The DNA methylation score improved upon Gleason sum for predicting metastatic-lethal progression and holds promise for risk stratification of men with aggressive tumors. This prognostic score warrants further evaluation as a tool for improving patient outcomes.

Keyphrases

radical prostatectomy
prostate cancer
dna methylation
genome wide
squamous cell carcinoma
gene expression
small cell lung cancer
middle aged
type diabetes
machine learning
metabolic syndrome