Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.
Bo ZhangThomas C SüdhofPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
Neuroligins are postsynaptic cell-adhesion molecules genetically linked to autism. However, the contributions of neuroligins to interneuron functions remain largely unknown. Here, we analyzed the role of neuroligins in cerebellar stellate interneurons. We deleted neuroligin-1, neuroligin-2, and neuroligin-3, the major cerebellar neuroligin isoforms, from stellate cells in triple NL123 conditional knock-out mice and analyzed synaptic responses by acute slice electrophysiology. We find that neuroligins are selectively essential for extrasynaptic NMDAR-mediated signaling, but dispensable for both AMPAR-mediated and inhibitory synaptic transmission. Our results reveal a critical and selective role for neuroligins in the regulation of NMDAR responses in cerebellar stellate interneurons.
Keyphrases
- cell adhesion
- induced apoptosis
- autism spectrum disorder
- liver failure
- intellectual disability
- gene expression
- oxidative stress
- computed tomography
- magnetic resonance imaging
- hepatitis b virus
- metabolic syndrome
- adipose tissue
- single cell
- drug induced
- signaling pathway
- cell death
- cell proliferation
- acute respiratory distress syndrome
- aortic dissection
- wild type
- mechanical ventilation