Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation.

Huanhuan LiuAnupama BinoySiqi RenThomas C MartinoAnna E MillerCraig R G WillisShivakumar R VeerabhadraiahAbhijit SukulMichael J JurynecShouan Zhu

Published in: bioRxiv : the preprint server for biology (2024)

We found that Sirt5 mediated MaK is an important regulator of chondrocyte cellular metabolism and dysregulation of Sirt5-MaK could be an important mechanism underlying aging and obesity associated OA development.

Keyphrases

oxidative stress
ischemia reperfusion injury
metabolic syndrome
knee osteoarthritis
insulin resistance
rheumatoid arthritis
weight loss
amino acid
transcription factor
weight gain
adipose tissue
protein protein
binding protein