Morphologic and molecular analysis of early-onset gastric cancer.
Namrata SetiaCindy X WangAngela LagerSteve MaronStuti ShroffNicole ArndtBryan PetersonSonia S KupferChangqing MaJoseph MisdrajiDaniel CatenacciJohn HartPublished in: Cancer (2020)
Early-onset gastric cancer has distinct genomic alterations, such as CDH1 mutations, but shares with traditional gastric cancers a high frequency of TP53 mutations and the TP53 mutagenic signature. Diffuse and indeterminate histologic types and the presence of a CDH1 mutation are associated with worse overall survival. Endogenous factors leading to cytosine deamination and potential germline alterations in moderate-penetrance cancer susceptibility genes may be implicated in the pathogenesis of these cancers.
Keyphrases
- early onset
- high frequency
- transcranial magnetic stimulation
- late onset
- papillary thyroid
- childhood cancer
- squamous cell
- genome wide
- low grade
- copy number
- dna repair
- lymph node metastasis
- climate change
- bioinformatics analysis
- dna methylation
- squamous cell carcinoma
- dna damage
- fine needle aspiration
- genome wide identification
- transcription factor
- genome wide analysis