Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study.
Jingyun LiAngela Lin ChiewGeoffrey K IsbisterStephen B DuffullPublished in: Clinical toxicology (Philadelphia, Pa.) (2021)
A joint parent-metabolite model to describe time-course profiles of both IR and MR paracetamol and its metabolites APAPG and APAPS concentrations was developed. Simulations from the model showed that toxicity assessment based on the 150 mg/L nomograms is not suitable in MR paracetamol overdoses.